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KMID : 0616120090400030196
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 3 p.196 ~ p.204
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Effects of Herbal Complex on Blood Glucose in Streptozotocin-induced Diabetic Rats and in Mice Model of Metabolic Syndrome
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Park Han-Seok
Lee Yeon-Sil
Choi Se-Jin
Kim Jin-Kyu
Lee Yun-Lyul
Kim Hyun-Gwen
Koo Sam-Hoi
Ku Dae-Hoy
Ki Seung-Il
Lim Soon-Sung
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Abstract
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This study was carried out to investigate the in vivo and in vitro inhibitory effect of a traditional herbal complex
(HC) extract prepared from a mixture of four oriental herbs (Dioscorea Rhizoma, Glycine soja Sieb. et Zucc, Bombycis corpus, Fermented Glycine soja) that have been widely used for the treatment and prevention of diabetes mellitus on hyperglycemia. The water extract of HC showed potent inhibitory effect on α-glucosidase with IC50 value of 1.24 mg/mL. Additionally, the ethanol extract of HC was also found to exhibit significant inhibitory effect against protein tyrosine phosphatase 1β (PTP1β), which is known as a major regulator of both insulin and leptin signaling. In the PTP1β inhibitory assay, the most active n-hexane fraction obtained from the ethanol extract of HC, was identified as a mixture of fatty acid derivatives by gas chromatography?mass spectrometry (GC-MS). In high-fat diet-low dose streptozotocin (STZ)-induced diabetic rat, the water extract of HC improved the oral glucose intolerance as compared with rosiglitazone. HC also caused a marked decrease of body weight and fasting blood glucose and a significant improvement on glucose tolerance in metabolic syndrome mice model. These findings support that this traditional HC may be useful in the control of blood glucose in diabetes mellitus and metabolic syndrome.
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KEYWORD
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Herbal Complex, Protein Tyrosine Phosphatase 1β, Diabetes, Metabolic Syndrome
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